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Thursday, 12 July 2018

And Now for Something Completely Deferent


I’ve wrote before on the subject of unusual presentations of endometriosis, mostly because they’re like a fascinating puzzle to unpick within the vast puzzle that is endometriosis, like a jigsaw made of rubik’s cubes. But it’s not only the inherent fascination with such oddities that interests me, but the fact that the unusual ways in which endometriosis occurs could tell us a great deal about how endometriosis arises in the vast majority of other cases. Perhaps the most unusual presentation is male endometriosis. I’m not talking about endometriosis is trans-men (mostly because there is little to no research in this area, which is a definite shame and something I would like to see rectified sooner rather than later), but endometriosis in cis-gendered males who, by all logic, should not be able to develop a condition that is typically associated with the uterus. It is something that should be impossible, but it happened anyway. I have covered this topic before, but there was another case report published in January of this year so I think its worth looking at this one and going over what this could mean for endometriosis in the wider context.

The case report (link to the full text article here) describes a 40 year old man who came to his doctor with intermittent abdominal pain moving down his right side, described as “a constant dull ache with intermittent sharp pains” and “feelings of being bloated with progressive abdominal discomfort”, is it sounding familiar to anyone yet? Aside from asthma and being a bit obese the patient was medically unremarkable, no long-term serious illnesses or unusual medical conditions to hint at what might be the cause of his pain, he didn’t even present with any other symptoms that would give the doctors a clue as to what the cause of the pain might be (like painful urination, painful/bloody bowel movements or diarrhoea that may indicate an infection or gastrointestinal issue). So the doctors decided to perform a series of scan and found a mass, measuring roughly 9cm x 5.6cm (about the size of a avocado) between the bladder and the rectum apparently arising from the vas deferens (the tube that takes sperm from the testicles to the prostate and the inspiration for the incredibly tortured pun the title of this post). If you look at figure (a) at this link you’ll be able to see it as the roundish, pear shaped object roughly halfway between the small white bit near the bottom and the long white spine.

The doctors concluded the mass was a fluid filled cyst of some kind so decided to perform a laparoscopy that then became a laparotomy to fully explore the pelvic area and remove the mass, which was then sent away to the lab for testing. When the results came back they had a “highly unexpected” diagnosis of endometriosis. The cyst was filled with a cloudy brown fluid while the lining was composed of endometrial epithelium and stroma (the cells you would normally find in the endometrium or an endometriotic cyst). In fact, the description of the cyst they found has some definite similarities to ovarian endometriotic cysts. The question posed then is, where on earth did it come from? Perhaps the few other case reports of endometriosis in males could help answer this.

The authors of this case report have gone through the literature and found all the other cases of endometriosis in males, which you can find in the link to the full text, but I’ll briefly summarise below

Patient Age
Location of Endometriosis
Symptoms
Risk Factors
Treatment
78
Prostatic urethral crest
Not reported
Estrogen therapy for prostate cancer
Not reported
52
Attached to bladder
Stabbing pelvic pain
Surgery for hernia, liver chirrhosis
Surgery
69
Paratestis
Swelling of the testis
Hormone therapy for prostate cancer
Surgical removal of testes
27
Epididymis
Scrotal pain
None reported
Surgery
82
Between vas deferens and testes
Mass felt on epididymis
Hormone therapy for prostate cancer
Surgical removal of testes
52
Attached to bladder
Lower abdomen pain
Surgery for hernia, liver chirrhosis
Surgery
83
Lower abdominal wall
Not reported
Hormone therapy for prostate cancer
Not reported
80
Bladder
Not reported
Hormone therapy for prostate cancer
Not reported
50
Bladder
Blood in urine
Hormone therapy for prostate cancer
Surgery
43
Paratestis
Abdominal pain
Cancer of the testes
Surgical removal of left testicle
73
Ureterovesical junction
Swelling of the kidney
Hormone therapy for prostate cancer
Not reported
49
Ductus deferens
Discovered during hernia repair
Surgery for hernia
Surgery
74
Ureteral orifice
Blood in urine
Hormone therapy for prostate cancer
Surgery
46
Found within a tumour of the testes
Cyst next to tumour
Obesity
Surgical removal of right testicle
Not reported
Scrotum
Not reported
Hormone therapy for prostate cancer
Not reported
40
Vas deferens
Abdominal pain
Obesity
Surgery

This is very much a simplified version of all the data in the published paper, it contains a brief overview of all the important information that was given. Do you notice any common themes running through these case reports? In the risk factors column there is an awfully high incidence of hormone therapy for prostate cancer, usually using estrogen-like drugs. In addition to this, other cases had increased estrogen due to liver cirrhosis, or obesity. Estrogen cant be working on its own though; liver cirrhosis and certainly obesity are common enough, yet what you see in the table above are all the cases of this unusual presentation of endometriosis known in the world (at the time I’m writing this anyway).

A few theories on the origin of endometriosis could provide an explanation for what we are seeing here. One of the more popular ones suggests that, during the development of a human embryo, pieces of tissue get left behind that can go on to be stimulated by estrogen to become endometriosis. As the embryo is developing it has two sets of tubes that will go on to form the reproductive organs, one called the Mullerian duct, the other, the Wolffian ducts, and the gonads. Given a certain set of biological signals from the embryo one set of ducts will regress and the other will develop into reproductive organs and the gonads will develop into either testes or ovaries. In basic terms if the embryo has a Y chromosome (and the SRY gene) the Mullerian ducts will regress and the Wolffian ducts will develop into all the various tubes leading from the testes and through the prostate. If the embryo doesn’t have the SRY gene, the Wolffian ducts regress and the fallopian tubes, uterus, cervix and vagina develop.

However, if the Mullerian ducts don’t regress completely they could, in theory, leave behind patches of tissue capable of developing into endometrial-like tissue when stimulated by estrogen, which I’ve talked about before. If this were the case we would expect endometriosis to develop around the bladder and ducts leading from the testes to the prostate, indeed this is what we see if we look at the table above. While this is indeed an attractive theory, there has been very little scientific testing done to show that these patches of Mullerian remnant tissue exist or that they can transform into endometriosis when stimulated with estrogen.

One of the most important factors to take note of here is menstruation, or rather the lack of thereof. None of the males in these case reports have a uterus, or have periods, so this has wider implications for the theories of endometriosis origin in women. Certainly, it casts serious doubt over the prevailing theory of endometriosis origin, retrograde menstruation, which states that pieces of endometrium are refluxed back into the pelvic cavity, where they implant and grow into endometriotic lesions. Sometimes understanding how something doesn’t work can be as important as understanding how it does work.

4 comments:

  1. I am Shelley from Los Angeles,California, I want to testify on how i got cured from fibroid, I have suffered from fibroid since the year 2011 with so mush pain,that i have to spend so mush money getting pain relief in the hospital, and I have visited several doctor ,but all to no avail, my world was gradually coming to an end because of the pain during my menstrual period until i saw a post in a health forum about a herbal Dr Williams who use herbal portion in curing people from different kind of diseases including fibroid, at first i doubted if it we be able to shrink the 9cm large fibroid in my womb, but i decided to give it a try, when i contacted this herbal doctor via his email, he prepared a herbal portion and sent it to me via courier service, when i received this herbal medicine, he gave me step by step instructions on how to apply it, when i applied it as instructed, i was completely free from fibroid just for 1 months of usage,i we recommend this to all my friend family in the world today who still suffering from fibroid you can contact him through his email on drwilliams098675@gmail.com for help.

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    1. Hey Michaele, Is Endometriosis causing you to give up on your dream of becoming a parent? Don’t give up just yet. At IVF Spring Fertility Clinic , one of the top fertility clinics in India, we find the exact cause of your condition and devise a plan for treatment. Our state-of-the-art technology and latest techniques accurately determine if your condition has occurred due to a blockage, infection, genetic disease, or something else, and appropriately treat the condition to possible reverse it. Our fertility specialists are experts in their field, and work together to discuss the best treatment plan for your specific condition. We also give you some options on further fertility treatments such as IVF or ICSI, in case you and your partner are looking to conceive a child. Our customized treatments and high success rates have resulted in a 96% satisfaction rate, which is the best in the industry. With regular counseling sessions, and a personalized service and treatment, we ensure that you feel a part of your fertility journey, and not just at the mercy of the doctors around you. At IVF Spring, Mumbai, we urge you to never stop believing, as your silver lining is just around the corner.

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  2. A big hello to the author, just read your blog ‘To adopt or not’ and was temporarily unable to react cause to be honest this is a very sensitive topic and still you managed to present it in a very beautiful manner, and concluding it to a realistic message that i should say you definitely nailed writing this article. You truly deserve a lot of appreciation for this blog. I wish this articles of yours reach masses so they could find how to deal with problems in such situations. Guess what?? I’m a Surrogacy Consultant and I have written blogs related to your topic too! The surrogacy cost in Australia can get quite high, depending on the agency you go to, as well as the kind of treatment you require, so it is vital to consult trusted agencies that value professionalism. Global Star Surrogacy is a leading ethical IVF and Surrogacy Agency, offering surrogacy services all over the world. Our aim is to make the surrogacy process pleasant and smooth for both parties involved. With over 10 years of experience, Global Star as an International Surrogacy Agency has helped more than 100 couples fulfill their dream of parenthood. Consult Global Star Surrogacy, for a world class IVF and surrogacy experience. Please find time to read Surrogacy in India and don’t forget to share your thoughts on it!

    Thank you!
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  3. As a sign of gratitude for how my wife was saved from fibroid, i decided to reach out to those still suffering from this.
    My wife suffered from fibroid for more than 20 year of marriage after our first son and it was really tough and heartbreaking for me because she was my all and the symptoms were terrible, she had irregular and painful menstrual flow and the size of it was 5cm, and she always complain of stomach pain. we tried various therapies prescribed by our neurologist but none could cure her. I searched for a cure and i saw a testimony by someone who was cured and so many other with similar body problem, and she left the contact of the doctor who had the natural cure to fibroid. I never imagined fibroid has a natural cure if not surgery not until i contacted him and he assured me my wife will be fine. I got the herbal medication he recommended and my wife used it as instructed by Dr Williams, and in one months time we went to the hospital for scan and the doctor confirmed that there is no trace of fibroid and now she is fully okay, even up till this moment she is so full of life. fibroid has a cure and it is a herbal cure contact the doctor for more info on drwilliams098675@gmail.com on how to get his medication.

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